What is Chronic Endometritis?
Chronic endometritis (CE) is a condition involving the breakdown of the peaceful co-existence between microorganisms and the host immune system in the endometrium. A majority of CE cases produce no noticeable signs or mild symptoms, and the prevalence rate of CE has been found to be approximately 10%.

Is chronic endometritis serious?
In most cases, the condition goes away with antibiotics. Untreated endometritis can lead to more serious infections and complications. Rarely, it may be associated with a diagnosis of endometrial cancer.

How common is chronic endometritis?
Chronic endometritis is defined as a localized inflammatory condition of the endometrial mucosa, the inner lining of the uterine cavity. It is present in 10-11% of the general population, with a higher frequency in infertile women. Fibroids, Polyps, Bacterial Vaginosis and IUDs cause irritation of the endometrial lining that can lead to mild cases of chronic endometritis.

What are chronic endometritis symptoms?
Chronic endometritis (CE) is generally asymptomatic or has vague symptoms, such as abnormal uterine bleeding, pelvic pain, leukorrhea, Implantation Failure in IVF.

Diagnosis of CE
Usually, CE is diagnosed by endometrial biopsy, and the presence of plasma cells in the endometrial stroma is the generally accepted histological diagnostic criterion for CE. Hysteroscopy is another powerful tool for diagnosing CE. The signs that favor the diagnosis of chronic endometritis in hysteroscopy include inflammation (focal or diffuse hyperemia, stromal edema, presence of micropolyps and the typical strawberry aspect) on the endometrial surface.

What is the best treatment for endometritis?
The combination of clindamycin and gentamicin is appropriate for the treatment of endometritis. Regimens with good activity against penicillin‐resistant anaerobic bacteria are better than those with poor activity against penicillin‐resistant anaerobic bacteria.

This article has been approved by Dr. Parisa Mostafaei.