Treatment Workflow for Patients at Royan Advanced infertility Center
Starting Treatment at Royan


Appointments can be scheduled via phone, online, or in person ⇒ On the scheduled date, the couple should visit the clinic for consultation and medical file registration ⇒ 


Male Partner: On the scheduled day, the semen analysis will be performed in the morning, and the consultation with the male partner will take place in the afternoon ⇒ Additional procedures may be required before starting infertility treatment. These may include repeat semen analysis, testicular biopsy, chromosomal analysis, or specialized treatments such as varicocele surgery.  ⇒ If no further procedures are needed, the appropriate treatment method –such as IUI, IVF, ICSI, or Ind – will be determined after the female partner’s consultation results are reviewed.   ⇒ The male partner’s next visit will be on the day of the egg retrieval procedure, to provide a sperm sample after the female partner has received her prescribed medications. 


Female Partner: On the scheduled day, the medical examination and requested tests for the female partner will be conducted during the morning and afternoon shift, based on the pre-arranged appointment .  ⇒ Depending on the patient’s medical history, further diagnostic evaluations such as hysteronsalpingography (HSG), Laparoscopy, Doppler ultrasound, or other specialized assessments may be necessary. / If no specialized diagnostic tests are required, the patient  will return once all test results are ready to determine the best treatment plan.  ⇒ Once diagnostic procedures are complete and treatment method is determined, the next steps will be planned accordingly.    
⇒ The female partner will return on the second or third day of her menstrual cycle to begin treatment. 
Based on the woman's age and hormonal test results — which reflect ovarian function — the type and dosage of ovarian stimulation medications will be prescribed accordingly.  ⇒  If the selected treatment is IVF (In Vitro Fertilization) or  ICSI (Intracytoplasmic Sperm Injection)   ⇒   The physician will recommend one of the following two stimulation protocols based on the patient’s condition: 1. Short Protocol: Duration of injectable medications is less than one month. 
2. Long Protocol:  Duration of injectable medications is approximately one and a half months.
           ⇒   During the treatment cycle, the patient must visit the center several times for ultrasound monitoring and adjustment of medication dosage based on ovarian response.
           ⇒ When the ovarian follicles reach a size of 18–20 mm, the patient will be instructed to receive an HCG injection to trigger ovulation.
              ⇒  Approximately 34–36 hours after HCG injection, egg retrieval is performed under anesthesia in the operating room.         
                 ⇒  On the day of egg retrieval, the husband provides a semen sample. The sperm sample is then washed, cultured, and prepared for fertilization.
                   IVF/ICSI Procedure:

IVF: The prepared sperm and mature eggs are placed together in a culture dish for natural fertilization.     
ICSI: A single prepared sperm is directly injected into the cytoplasm of each mature egg.
       ⇒  Fertilization occurs, leading to the formation of embryos.
       ⇒ The embryos are either transferred to the uterus 38–72 hours after egg retrieval, or frozen for future use.
If IUI is the chosen treatment method ⇒ Once medication begins, the patient will need to visit the center several times during the menstrual cycle for ultrasound monitoring to evaluate the ovaries' response to the prescribed drugs. ⇒ When the ovarian follicles reach a size of 18–20 mm, the patient will be instructed to receive an HCG injection to trigger ovulation. ⇒ In certain cases, depending on the patient's medical condition, an alternative medication may be used instead of HCG.  ⇒ The patient will return to the center for the IUI procedure approximately 36 hours after the HCG injection.                       On the day of the procedure:  
•    A semen sample is collected from the husband
•    The sperm is washed and prepared in a nutrient-rich medium  
•    The processed sample is then injected into the uterus of the female partner
    ⇒ 14 to 17 days later, an HCG blood test will be performed to determine the outcome of the treatment.